[HTML][HTML] DJ-1 positively regulates the androgen receptor by impairing the binding of PIASxα to the receptor
K Takahashi, T Taira, T Niki, C Seino… - Journal of Biological …, 2001 - ASBMB
DJ-1 was first identified as a novel candidate of the oncogene product that transformed
mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an
infertility-related protein that was reduced in rat sperm treated with sperm toxicants that
cause infertility in rats. To determine the functions of DJ-1, cDNAs encoding DJ-1-binding
proteins were screened by the yeast two-hybrid method. Of several proteins identified,
PIASxα/ARIP3, a modulator of androgen receptor (AR), was first characterized as the DJ-1 …
mouse NIH3T3 cells in cooperation with an activated ras. Later DJ-1 was also found to be an
infertility-related protein that was reduced in rat sperm treated with sperm toxicants that
cause infertility in rats. To determine the functions of DJ-1, cDNAs encoding DJ-1-binding
proteins were screened by the yeast two-hybrid method. Of several proteins identified,
PIASxα/ARIP3, a modulator of androgen receptor (AR), was first characterized as the DJ-1 …
