Inhibition of matrix metalloproteinases attenuates anti-Thy1. 1 nephritis.
K Steinmann-Niggli, R Ziswiler, M Küng… - Journal of the …, 1998 - journals.lww.com
There is accumulating evidence that matrix metallo-proteinases (MMP) play a prominent role
in glomerular inflammatory diseases. The aim of the present study was to determine the anti-
inflammatory effects of the synthetic MMP inhibitor BB-1101 in acute anti-Thy1. 1 nephritis.
Sixty-three male Wistar rats were studied: healthy rats (n= 9), treated healthy rats (n= 9),
nephritic rats (n= 18), and treated nephritic rats (n= 27). BB-1101 therapy (30 mg/kg body wt
per d) of nephritic animals was initiated either 2 d before (n= 18) or 2 d after (n= 9) disease …
in glomerular inflammatory diseases. The aim of the present study was to determine the anti-
inflammatory effects of the synthetic MMP inhibitor BB-1101 in acute anti-Thy1. 1 nephritis.
Sixty-three male Wistar rats were studied: healthy rats (n= 9), treated healthy rats (n= 9),
nephritic rats (n= 18), and treated nephritic rats (n= 27). BB-1101 therapy (30 mg/kg body wt
per d) of nephritic animals was initiated either 2 d before (n= 18) or 2 d after (n= 9) disease …