Extracellular matrix remodeling at the early stages of liver regeneration in the rat
T Kim, WM Mars, DB Stolz, BE Petersen… - Hepatology, 1997 - journals.lww.com
Previous studies have shown that activity of urokinase-type plasminogen activator (u-PA)
increases very rapidly (within 1 minute) after partial hepatectomy. In view of the well-
recognized roles of u-PA as one of the major initiators of the matrix proteolysis cascade and
as an activator of plasminogen and hepatocyte growth factor (HGF), we studied matrix
degradation in liver shortly after partial hepatectomy. The activation of plasminogen to
plasmin following partial hepatectomy was examined by Western blot analysis, and a small …
increases very rapidly (within 1 minute) after partial hepatectomy. In view of the well-
recognized roles of u-PA as one of the major initiators of the matrix proteolysis cascade and
as an activator of plasminogen and hepatocyte growth factor (HGF), we studied matrix
degradation in liver shortly after partial hepatectomy. The activation of plasminogen to
plasmin following partial hepatectomy was examined by Western blot analysis, and a small …