[HTML][HTML] Interferon β in multiple sclerosis: is IL-12 suppression the key?
CL Karp, CA Biron, DN Irani - Immunology today, 2000 - cell.com
CL Karp, CA Biron, DN Irani
Immunology today, 2000•cell.comRecently, much has been learned about the immunology of multiple sclerosis (MS).
However, a mechanistic understanding of currently employed immunomodulatory therapies
has lagged behind, hindering both the search for more effective agents and clearer insight
into the immunopathogenesis of MS. Christopher Karp and colleagues explore a unifying
hypothesis for the mechanism of action of interferon β in MS: suppression of interleukin 12
production.
However, a mechanistic understanding of currently employed immunomodulatory therapies
has lagged behind, hindering both the search for more effective agents and clearer insight
into the immunopathogenesis of MS. Christopher Karp and colleagues explore a unifying
hypothesis for the mechanism of action of interferon β in MS: suppression of interleukin 12
production.
Abstract
Recently, much has been learned about the immunology of multiple sclerosis (MS). However, a mechanistic understanding of currently employed immunomodulatory therapies has lagged behind, hindering both the search for more effective agents and clearer insight into the immunopathogenesis of MS. Christopher Karp and colleagues explore a unifying hypothesis for the mechanism of action of interferon β in MS: suppression of interleukin 12 production.
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