Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes
JE Schmitz, MJ Kuroda, S Santra, VG Sasseville… - Science, 1999 - science.org
JE Schmitz, MJ Kuroda, S Santra, VG Sasseville, MA Simon, MA Lifton, P Racz…
Science, 1999•science.orgClinical evidence suggests that cellular immunity is involved in controlling human
immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune
deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)–infected rhesus
monkey, was used to show that virus replication is not controlled in monkeys depleted of
CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from
monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that …
immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune
deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)–infected rhesus
monkey, was used to show that virus replication is not controlled in monkeys depleted of
CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from
monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that …
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)–infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
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