Migration patterns of dendritic cells in the rat: comparison of the effects of γ and UV-B irradiation on the migration of dendritic cells and lymphocytes
SF Oluwole, K Engelstad, C De Rosa, TST Wang… - Cellular …, 1991 - Elsevier
To further define the underlying mechanisms of immune suppression induced by UV-B
irradiation, we have examined the kinetics of homing patterns of in vitro UV-B-irradiated and
γ-irradiated-thoracic duct lymphocytes (TDL) compared to dendritic cells (DC). Our findings
show that 111 In-oxine-labeled TDL specifically home to the spleen, liver, lymph nodes, and
bone marrow with subsequent recirculation of a large number of cells from the spleen to
lymph nodes. In contrast, DC preferentially migrate to the spleen and liver with a relatively …
irradiation, we have examined the kinetics of homing patterns of in vitro UV-B-irradiated and
γ-irradiated-thoracic duct lymphocytes (TDL) compared to dendritic cells (DC). Our findings
show that 111 In-oxine-labeled TDL specifically home to the spleen, liver, lymph nodes, and
bone marrow with subsequent recirculation of a large number of cells from the spleen to
lymph nodes. In contrast, DC preferentially migrate to the spleen and liver with a relatively …
