Tumor necrosis factor: a master-regulator of leukocyte movement
JD Sedgwick, DS Riminton, JG Cyster, H Körner - Immunology today, 2000 - cell.com
JD Sedgwick, DS Riminton, JG Cyster, H Körner
Immunology today, 2000•cell.comTumor necrosis factor (TNF)-mediated activities are potentially numerous, although in TNF-
deficient (−/−) mice, altered spatial orientation of leukocytes within tissues is the
predominant phenotype. Here, we propose that TNF plays a fundamental role in the control
of leukocyte movement by virtue of a pivotal role in regulation of chemokine expression.
deficient (−/−) mice, altered spatial orientation of leukocytes within tissues is the
predominant phenotype. Here, we propose that TNF plays a fundamental role in the control
of leukocyte movement by virtue of a pivotal role in regulation of chemokine expression.
Abstract
Tumor necrosis factor (TNF)-mediated activities are potentially numerous, although in TNF-deficient (−/−) mice, altered spatial orientation of leukocytes within tissues is the predominant phenotype. Here, we propose that TNF plays a fundamental role in the control of leukocyte movement by virtue of a pivotal role in regulation of chemokine expression.
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