[HTML][HTML] Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin
V Lefebvre, MC Máchin, MP Louckx, MH Rider… - Journal of Biological …, 1996 - ASBMB
Incubation of isolated rat cardiomyocytes with insulin increased 2-deoxyglucose uptake,
glycogen synthesis, and fructose 2, 6-bisphosphate content. Half-maximal effects were
obtained with 1-2 nM insulin. The insulin-induced increase in fructose 2, 6-bisphosphate
content was preceded by a 2-3-fold activation of 6-phosphofructo-2-kinase, which was
independent of glucose transport. Insulin activated phosphatidylinositol 3-kinase and p70
ribosomal S6 kinase (p70 S6 kinase), but had no significant effect on mitogen-activated …
glycogen synthesis, and fructose 2, 6-bisphosphate content. Half-maximal effects were
obtained with 1-2 nM insulin. The insulin-induced increase in fructose 2, 6-bisphosphate
content was preceded by a 2-3-fold activation of 6-phosphofructo-2-kinase, which was
independent of glucose transport. Insulin activated phosphatidylinositol 3-kinase and p70
ribosomal S6 kinase (p70 S6 kinase), but had no significant effect on mitogen-activated …